1ibc
From Proteopedia
(New page: 200px<br /> <applet load="1ibc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ibc, resolution 2.73Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1IBC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IBC OCA]]. | + | 1IBC is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ACE as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36]]. Structure known Active Sites: S1, S2, S3 and S4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IBC OCA]]. |
==Reference== | ==Reference== | ||
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)., Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA, Chem Biol. 1997 Feb;4(2):149-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9190289 9190289] | A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)., Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA, Chem Biol. 1997 Feb;4(2):149-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9190289 9190289] | ||
| + | [[Category: Caspase-1]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:48:57 2007'' |
Revision as of 11:44, 30 October 2007
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CRYSTAL STRUCTURE OF INHIBITED INTERLEUKIN-1BETA CONVERTING ENZYME
Overview
BACKGROUND: Interleukin-1beta converting enzyme (ICE/caspase-1) is the, protease responsible for interleukin-1beta (IL-1beta) production in, monocytes. It was the first member of a new cysteine protease family to be, identified. Members of this family have functions in both inflammation and, apoptosis. RESULTS: A novel method for identifying protease specificity, employing a positional-scanning substrate library, was used to determine, the amino-acid preferences of ICE. Using this method, the complete, specificity of a protease can be mapped in the time required to perform, one assay. The results indicate that the optimal tetrapeptide recognition, sequence for ICE is WEHD, not YVAD, as previously believed, and this led, to the synthesis of an unusually potent aldehyde inhibitor, ... [(full description)]
About this Structure
1IBC is a [Single protein] structure of sequence from [Homo sapiens] with ACE as [ligand]. Active as [Caspase-1], with EC number [3.4.22.36]. Structure known Active Sites: S1, S2, S3 and S4. Full crystallographic information is available from [OCA].
Reference
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)., Rano TA, Timkey T, Peterson EP, Rotonda J, Nicholson DW, Becker JW, Chapman KT, Thornberry NA, Chem Biol. 1997 Feb;4(2):149-55. PMID:9190289
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