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1d76

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(New page: 200px<br /><applet load="1d76" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d76, resolution 1.300&Aring;" /> '''CRYSTAL AND MOLECUL...)
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caption="1d76, resolution 1.300&Aring;" />
'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''<br />
'''CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS'''<br />
==Overview==
==Overview==
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The crystal and molecular structure of d(CGUA'CG)2 (where A' is, 2-aminoadenine) has been determined and refined to an R factor of 13.8%, for data 8.0-1.3 A. The structure is very similar to the original Z-DNA, structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., &amp; Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs, in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to, explain the ZI-ZII conformational pattern found in many Z-DNA structures.
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The crystal and molecular structure of d(CGUA'CG)2 (where A' is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 A. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., &amp; Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures.
==About this Structure==
==About this Structure==
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1D76 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D76 OCA].
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1D76 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D76 OCA].
==Reference==
==Reference==
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1390739 1390739]
Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1390739 1390739]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Berman, H.M.]]
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[[Category: Berman, H M.]]
[[Category: Gaffney, B.]]
[[Category: Gaffney, B.]]
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[[Category: Ginell, S.L.]]
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[[Category: Ginell, S L.]]
[[Category: Jones, R.]]
[[Category: Jones, R.]]
[[Category: Schneider, B.]]
[[Category: Schneider, B.]]
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[[Category: z-dna]]
[[Category: z-dna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:38:43 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:13:39 2008''

Revision as of 10:13, 21 February 2008

Image:1d76.gif

1d76, resolution 1.300Å

Drag the structure with the mouse to rotate

CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS

Overview

The crystal and molecular structure of d(CGUA'CG)2 (where A' is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 A. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., & Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921] and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures.

About this Structure

1D76 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers., Schneider B, Ginell SL, Jones R, Gaffney B, Berman HM, Biochemistry. 1992 Oct 13;31(40):9622-8. PMID:1390739

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