3cde
From Proteopedia
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{{STRUCTURE_3cde| PDB=3cde | SCENE= }} | {{STRUCTURE_3cde| PDB=3cde | SCENE= }} | ||
===Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor=== | ===Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor=== | ||
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{{ABSTRACT_PUBMED_18457949}} | {{ABSTRACT_PUBMED_18457949}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3cde]] is a 2 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDE OCA]. | |
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| + | ==See Also== | ||
| + | *[[RNA polymerase|RNA polymerase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018457949</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
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[[Category: Viral nucleoprotein]] | [[Category: Viral nucleoprotein]] | ||
[[Category: Virion]] | [[Category: Virion]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 4 14:41:36 2009'' | ||
Revision as of 06:31, 26 July 2012
Contents |
Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
Template:ABSTRACT PUBMED 18457949
About this Structure
3cde is a 2 chain structure of RNA polymerase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072
Categories: Hepatitis c virus | RNA-directed RNA polymerase | Han, Q. | Kissinger, C R. | Showalter, R E. | Zhao, Q. | Atp-binding | Host-virus interaction | Hydrolase | Metal-binding | Nucleotide-binding | Nucleotidyltransferase | Protein-ligand complex | Ribonucleoprotein | Rna replication | Rna-binding | Rna-directed rna polymerase | Transcription | Transcription regulation | Transferase | Viral nucleoprotein | Virion
