1d96
From Proteopedia
(New page: 200px<br /><applet load="1d96" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d96, resolution 2.000Å" /> '''MOLECULAR STRUCTURE...) |
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| - | [[Image:1d96.gif|left|200px]]<br /><applet load="1d96" size=" | + | [[Image:1d96.gif|left|200px]]<br /><applet load="1d96" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1d96, resolution 2.000Å" /> | caption="1d96, resolution 2.000Å" /> | ||
'''MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA'''<br /> | '''MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA | + | The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities. |
==About this Structure== | ==About this Structure== | ||
| - | 1D96 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | + | 1D96 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D96 OCA]. |
==Reference== | ==Reference== | ||
Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA., Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A, Nature. 1982 Oct 14;299(5884):601-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6181416 6181416] | Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA., Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A, Nature. 1982 Oct 14;299(5884):601-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=6181416 6181416] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Boeckel, S | + | [[Category: Boeckel, S A.A Van.]] |
| - | [[Category: Boom, J | + | [[Category: Boom, J H.Van.]] |
[[Category: Fujii, S.]] | [[Category: Fujii, S.]] | ||
| - | [[Category: Marel, G | + | [[Category: Marel, G A.Van Der.]] |
[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
| - | [[Category: Wang, A | + | [[Category: Wang, A H.J.]] |
[[Category: a-dna/rna]] | [[Category: a-dna/rna]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:14:14 2008'' |
Revision as of 10:14, 21 February 2008
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MOLECULAR STRUCTURE OF R(GCG)D(TATACGC): A DNA-RNA HYBRID HELIX JOINED TO DOUBLE HELICAL DNA
Overview
The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.
About this Structure
1D96 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA., Wang AH, Fujii S, van Boom JH, van der Marel GA, van Boeckel SA, Rich A, Nature. 1982 Oct 14;299(5884):601-4. PMID:6181416
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