This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1da2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1da2, resolution 1.700&Aring;" /> '''MOLECULAR AND CRYST...)
Line 1: Line 1:
-
[[Image:1da2.gif|left|200px]]<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1da2.gif|left|200px]]<br /><applet load="1da2" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1da2, resolution 1.700&Aring;" />
caption="1da2, resolution 1.700&Aring;" />
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''<br />
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''<br />
==Overview==
==Overview==
-
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its, hydrogen-bonding potential, since it forms stable base-pairs with both, adenine and guanine in oligomer duplexes. To investigate the base-pair, geometry, the structure of d(CGCGmo4CG) has been determined by, single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2, crystallized in a left-handed double helical structure (Z-type)., Refinement using 2559 reflections between 10 and 1.7 A converged with a, final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The, orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell, dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is, of the wobble type, with mo4C in the imino form, and the methoxy group in, the syn configuration.
+
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.
==About this Structure==
==About this Structure==
-
1DA2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].
+
1DA2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].
==Reference==
==Reference==
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2258939 2258939]
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2258939 2258939]
[[Category: Protein complex]]
[[Category: Protein complex]]
-
[[Category: Brown, D.M.]]
+
[[Category: Brown, D M.]]
[[Category: Kennard, O.]]
[[Category: Kennard, O.]]
-
[[Category: Lin, P.K.T.]]
+
[[Category: Lin, P K.T.]]
-
[[Category: Meervelt, L.Van.]]
+
[[Category: Meervelt, L Van.]]
-
[[Category: Moore, M.H.]]
+
[[Category: Moore, M H.]]
[[Category: double helix]]
[[Category: double helix]]
[[Category: modified]]
[[Category: modified]]
[[Category: z-dna]]
[[Category: z-dna]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:51:43 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:14:31 2008''

Revision as of 10:14, 21 February 2008

Image:1da2.gif

1da2, resolution 1.700Å

Drag the structure with the mouse to rotate

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA

Overview

The base analogue N4-methoxycytosine (mo4C) is ambivalent in its hydrogen-bonding potential, since it forms stable base-pairs with both adenine and guanine in oligomer duplexes. To investigate the base-pair geometry, the structure of d(CGCGmo4CG) has been determined by single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2 crystallized in a left-handed double helical structure (Z-type). Refinement using 2559 reflections between 10 and 1.7 A converged with a final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is of the wobble type, with mo4C in the imino form, and the methoxy group in the syn configuration.

About this Structure

1DA2 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:2258939

Page seeded by OCA on Thu Feb 21 12:14:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1da2"
Personal tools