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3bht

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Image:3bht.png

Template:STRUCTURE 3bht

Contents

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3

Template:ABSTRACT PUBMED 17804748

About this Structure

3bht is a 4 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Res. 2007 Sep 1;67(17):8325-34. PMID:17804748 doi:67/17/8325
  • Echalier A, Bettayeb K, Ferandin Y, Lozach O, Clement M, Valette A, Liger F, Marquet B, Morris JC, Endicott JA, Joseph B, Meijer L. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. J Med Chem. 2008 Feb 28;51(4):737-51. Epub 2008 Jan 31. PMID:18232649 doi:10.1021/jm700940h

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OCA

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