1drs
From Proteopedia
(New page: 200px<br /><applet load="1drs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1drs" /> '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTA...) |
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'''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN'''<br /> | '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Dendroaspin is a short chain neurotoxin homologue from the venom of | + | Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold. |
==About this Structure== | ==About this Structure== | ||
| - | 1DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http:// | + | 1DRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Dendroaspis jamesoni kaimosae]] | [[Category: Dendroaspis jamesoni kaimosae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Hyde, E | + | [[Category: Hyde, E I.]] |
[[Category: Jaseja, M.]] | [[Category: Jaseja, M.]] | ||
[[Category: Lu, X.]] | [[Category: Lu, X.]] | ||
| - | [[Category: Sutcliffe, M | + | [[Category: Sutcliffe, M J.]] |
| - | [[Category: Williams, J | + | [[Category: Williams, J A.]] |
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:44 2008'' |
Revision as of 10:19, 21 February 2008
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THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN
Overview
Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
About this Structure
1DRS is a Single protein structure of sequence from Dendroaspis jamesoni kaimosae. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091
Page seeded by OCA on Thu Feb 21 12:19:44 2008
