1tx4
From Proteopedia
(New page: 200px<br /> <applet load="1tx4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tx4, resolution 1.65Å" /> '''RHO/RHOGAP/GDP(DOT)...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1TX4 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, ALF and GDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TX4 OCA]]. | + | 1TX4 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG, ALF and GDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: TS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TX4 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transition state]] | [[Category: transition state]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:52:40 2007'' |
Revision as of 11:47, 30 October 2007
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RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX
Overview
Small G proteins of the Rho family, which includes Rho, Rac and Cdc42Hs, regulate phosphorylation pathways that control a range of biological, functions including cytoskeleton formation and cell proliferation. They, operate as molecular switches, cycling between the biologically active, GTP-bound form and the inactive GDP-bound state. Their rate of hydrolysis, of GTP to GDP by virtue of their intrinsic GTPase activity is slow, but, can be accelerated by up to 10(5)-fold through interaction with rhoGAP, a, GTPase-activating protein that stimulates Rho-family proteins. As such, rhoGAP plays a crucial role in regulating Rho-mediated signalling, pathways. Here we report the crystal structure of RhoA and rhoGAP, complexed with the transition-state analogue GDP.AlF4- at 1.65 A, resolution. ... [(full description)]
About this Structure
1TX4 is a [Protein complex] structure of sequences from [Homo sapiens] with MG, ALF and GDP as [ligands]. Structure known Active Site: TS. Full crystallographic information is available from [OCA].
Reference
Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue., Rittinger K, Walker PA, Eccleston JF, Smerdon SJ, Gamblin SJ, Nature. 1997 Oct 16;389(6652):758-62. PMID:9338791
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