3dv1
From Proteopedia
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[[Image:3dv1.png|left|200px]] | [[Image:3dv1.png|left|200px]] | ||
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{{STRUCTURE_3dv1| PDB=3dv1 | SCENE= }} | {{STRUCTURE_3dv1| PDB=3dv1 | SCENE= }} | ||
===Crystal structure of human beta-secretase in complex with NVP-ARV999=== | ===Crystal structure of human beta-secretase in complex with NVP-ARV999=== | ||
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{{ABSTRACT_PUBMED_19195887}} | {{ABSTRACT_PUBMED_19195887}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3dv1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV1 OCA]. | + | [[3dv1]] is a 3 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV1 OCA]. |
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| + | ==See Also== | ||
| + | *[[Beta secretase|Beta secretase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019195887</ref><ref group="xtra">PMID:019195886</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Rondeau, J M.]] | [[Category: Rondeau, J M.]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: Aspartic protease]] | [[Category: Aspartic protease]] | ||
Revision as of 11:52, 26 July 2012
Contents |
Crystal structure of human beta-secretase in complex with NVP-ARV999
Template:ABSTRACT PUBMED 19195887
About this Structure
3dv1 is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. Epub 2009 Jan 22. PMID:19195887 doi:10.1016/j.bmcl.2009.01.055
- Machauer R, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Neumann U, Paganetti P. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1361-5. Epub 2009 Jan 19. PMID:19195886 doi:10.1016/j.bmcl.2009.01.036
