1dzi

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(New page: 200px<br /> <applet load="1dzi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dzi, resolution 2.1&Aring;" /> '''INTEGRIN ALPHA2 I DO...)
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'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''<br />
'''INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX'''<br />
==Overview==
==Overview==
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We have determined the crystal structure of a complex between the I domain, of integrin alpha2beta1 and a triple helical collagen peptide containing a, critical GFOGER motif. Three loops on the upper surface of the I domain, that coordinate a metal ion also engage the collagen, with a collagen, glutamate completing the coordination sphere of the metal. Comparison with, the unliganded I domain reveals a change in metal coordination linked to a, reorganization of the upper surface that together create a complementary, surface for binding collagen. Conformational changes propagate from the, upper surface to the opposite pole of the domain, suggesting both a basis, for affinity regulation and a pathway for signal transduction. The, structural features observed here may represent a general mechanism for, integrin-ligand recognition.
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We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1DZI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and NH2 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DZI OCA].
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1DZI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO:'>CO</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DZI OCA].
==Reference==
==Reference==
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[[Category: integrin]]
[[Category: integrin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:37:53 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:22:08 2008''

Revision as of 10:22, 21 February 2008

Image:1dzi.gif

1dzi, resolution 2.1Å

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INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX

Contents

Overview

We have determined the crystal structure of a complex between the I domain of integrin alpha2beta1 and a triple helical collagen peptide containing a critical GFOGER motif. Three loops on the upper surface of the I domain that coordinate a metal ion also engage the collagen, with a collagen glutamate completing the coordination sphere of the metal. Comparison with the unliganded I domain reveals a change in metal coordination linked to a reorganization of the upper surface that together create a complementary surface for binding collagen. Conformational changes propagate from the upper surface to the opposite pole of the domain, suggesting both a basis for affinity regulation and a pathway for signal transduction. The structural features observed here may represent a general mechanism for integrin-ligand recognition.

Disease

Known diseases associated with this structure: Glycoprotein Ia deficiency (1) OMIM:[192974], Neonatal alloimmune thrombocytopenia OMIM:[192974]

About this Structure

1DZI is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.

Reference

Structural basis of collagen recognition by integrin alpha2beta1., Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, Cell. 2000 Mar 31;101(1):47-56. PMID:10778855

Page seeded by OCA on Thu Feb 21 12:22:08 2008

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