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3kga
From Proteopedia
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{{STRUCTURE_3kga| PDB=3kga | SCENE= }} | {{STRUCTURE_3kga| PDB=3kga | SCENE= }} | ||
===Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor=== | ===Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor=== | ||
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{{ABSTRACT_PUBMED_20060294}} | {{ABSTRACT_PUBMED_20060294}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3kga]] is a 1 chain structure of [[Mitogen-activated protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGA OCA]. | |
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| + | ==See Also== | ||
| + | *[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020060294</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: 3-aminopyrazole scaffold]] | [[Category: 3-aminopyrazole scaffold]] | ||
[[Category: Activation loop deletion]] | [[Category: Activation loop deletion]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Atp-site kinase inhibitor]] | [[Category: Atp-site kinase inhibitor]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Scaffold hoping]] | [[Category: Scaffold hoping]] | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Small molecule inhibitor]] | [[Category: Small molecule inhibitor]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:55:56 2010'' | ||
Revision as of 13:13, 26 July 2012
Contents |
Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor
Template:ABSTRACT PUBMED 20060294
About this Structure
3kga is a 1 chain structure of Mitogen-activated protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Velcicky J, Feifel R, Hawtin S, Heng R, Huppertz C, Koch G, Kroemer M, Moebitz H, Revesz L, Scheufler C, Schlapbach A. Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1293-7. Epub 2009 Nov 3. PMID:20060294 doi:10.1016/j.bmcl.2009.10.138
Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Be, C. | Huppertz, C. | Izaac, A. | Kroemer, M. | Pflieger, D. | Scheufler, C. | Schlapbach, A. | Velcicky, J. | 3-aminopyrazole scaffold | Activation loop deletion | Atp-binding | Atp-site kinase inhibitor | Induced fit | Kinase | Novel hydrophobic pocket | Nucleotide-binding | Phosphoprotein | Scaffold hoping | Serine/threonine-protein kinase | Small molecule inhibitor | Transferase
