1usx
From Proteopedia
(New page: 200px<br /> <applet load="1usx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1usx, resolution 2.7Å" /> '''CRYSTAL STRUCTURE OF...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1USX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus]] with SIA, DAN and WIA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]]. | + | 1USX is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Newcastle_disease_virus Newcastle disease virus]] with SIA, DAN and WIA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]]. |
==Reference== | ==Reference== | ||
Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15016893 15016893] | Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15016893 15016893] | ||
| + | [[Category: Exo-alpha-sialidase]] | ||
[[Category: Newcastle disease virus]] | [[Category: Newcastle disease virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 30: | Line 31: | ||
[[Category: sialidase]] | [[Category: sialidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:55:31 2007'' |
Revision as of 11:50, 30 October 2007
|
CRYSTAL STRUCTURE OF THE NEWCASTLE DISEASE VIRUS HEMAGGLUTININ-NEURAMINIDASE COMPLEXED WITH THIOSIALOSIDE
Overview
Paramyxoviruses are the leading cause of respiratory disease in children., Several paramyxoviruses possess a surface glycoprotein, the, hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic, acid receptors, promotion of fusion, and removal of sialic acid from, infected cells and progeny virions. Previously we showed that Newcastle, disease virus (NDV) HN contained a pliable sialic acid recognition site, that could take two states, a binding state and a catalytic state. Here we, present evidence for a second sialic acid binding site at the dimer, interface of HN and present a model for its involvement in cell fusion., Three different crystal forms of NDV HN now reveal identical tetrameric, arrangements of HN monomers, perhaps indicative of the tetramer, association ... [(full description)]
About this Structure
1USX is a [Single protein] structure of sequence from [Newcastle disease virus] with SIA, DAN and WIA as [ligands]. Active as [Exo-alpha-sialidase], with EC number [3.2.1.18]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion., Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G, J Virol. 2004 Apr;78(7):3733-41. PMID:15016893
Page seeded by OCA on Tue Oct 30 13:55:31 2007
