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2vuk
From Proteopedia
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[[Image:2vuk.png|left|200px]] | [[Image:2vuk.png|left|200px]] | ||
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{{STRUCTURE_2vuk| PDB=2vuk | SCENE= }} | {{STRUCTURE_2vuk| PDB=2vuk | SCENE= }} | ||
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083=== | ===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083=== | ||
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{{ABSTRACT_PUBMED_18650397}} | {{ABSTRACT_PUBMED_18650397}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[2vuk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUK OCA]. | + | [[2vuk]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUK OCA]. |
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| + | ==See Also== | ||
| + | *[[P53|P53]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018650397</ref><ref group="xtra">PMID:017015838</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Boeckler, F M.]] | [[Category: Boeckler, F M.]] | ||
[[Category: Fersht, A R.]] | [[Category: Fersht, A R.]] | ||
[[Category: Joerger, A C.]] | [[Category: Joerger, A C.]] | ||
| - | [[Category: Acetylation]] | ||
[[Category: Activator]] | [[Category: Activator]] | ||
| - | [[Category: Alternative splicing]] | ||
[[Category: Anti-oncogene]] | [[Category: Anti-oncogene]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
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[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Covalent protein-rna linkage]] | [[Category: Covalent protein-rna linkage]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
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[[Category: P53 dna- binding domain]] | [[Category: P53 dna- binding domain]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Protein stabilization]] | [[Category: Protein stabilization]] | ||
[[Category: Second-site suppressor mutation]] | [[Category: Second-site suppressor mutation]] | ||
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[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
| - | [[Category: Ubl conjugation]] | ||
[[Category: Virtual screening]] | [[Category: Virtual screening]] | ||
| - | [[Category: Zinc]] | ||
Revision as of 18:21, 26 July 2012
Contents |
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083
Template:ABSTRACT PUBMED 18650397
About this Structure
2vuk is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. Epub 2008 Jul 23. PMID:18650397
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Categories: Homo sapiens | Boeckler, F M. | Fersht, A R. | Joerger, A C. | Activator | Anti-oncogene | Apoptosis | Cancer | Cell cycle | Covalent protein-rna linkage | Disease mutation | Dna binding | Dna-binding | Dna-binding protein | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Metal binding | Metal-binding | Methylation | Nuclear protein | Nucleus | P53 dna- binding domain | Phosphoprotein | Protein stabilization | Second-site suppressor mutation | Small-molecule drug | Superstable mutant | Surface crevice | Transcription | Transcription regulation | Tumor suppressor | Virtual screening
