2irz

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Revision as of 19:42, 26 July 2012

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Template:STRUCTURE 2irz

Contents 1 Crystal structure of human Beta-secretase complexed with inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal structure of human Beta-secretase complexed with inhibitor

Template:ABSTRACT PUBMED 17149856

About this Structure

2irz is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1). J Med Chem. 2006 Dec 14;49(25):7270-3. PMID:17149856 doi:10.1021/jm061046r
• Rajapakse HA, Nantermet PG, Selnick HG, Barrow JC, McGaughey GB, Munshi S, Lindsley SR, Young MB, Ngo PL, Holloway MK, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP. SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1885-9. Epub 2010 Feb 4. PMID:20176482 doi:10.1016/j.bmcl.2010.01.137