1fbn
From Proteopedia
(New page: 200px<br /><applet load="1fbn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fbn, resolution 1.6Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1fbn.gif|left|200px]]<br /><applet load="1fbn" size=" | + | [[Image:1fbn.gif|left|200px]]<br /><applet load="1fbn" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1fbn, resolution 1.6Å" /> | caption="1fbn, resolution 1.6Å" /> | ||
'''CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A'''<br /> | '''CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Fibrillarin is a phylogenetically conserved protein essential for | + | Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs during ribosomal biogenesis. The protein is the antigen for the autoimmune disease scleroderma. Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. The structure consists of two domains, with a novel fold in the N-terminal region and a methyltransferase-like domain in the C-terminal region. Mapping temperature-sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structure reveals that many of the mutations cluster in the core of the methyltransferase-like domain. |
==About this Structure== | ==About this Structure== | ||
| - | 1FBN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http:// | + | 1FBN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FBN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: BSGC, Berkeley | + | [[Category: BSGC, Berkeley Structural Genomics Center.]] |
[[Category: Boisvert, D.]] | [[Category: Boisvert, D.]] | ||
| - | [[Category: Kim, K | + | [[Category: Kim, K K.]] |
[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
| - | [[Category: Kim, S | + | [[Category: Kim, S H.]] |
[[Category: Wang, H.]] | [[Category: Wang, H.]] | ||
[[Category: berkeley structural genomics center]] | [[Category: berkeley structural genomics center]] | ||
| Line 29: | Line 29: | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:57 2008'' |
Revision as of 10:37, 21 February 2008
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CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A
Overview
Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs during ribosomal biogenesis. The protein is the antigen for the autoimmune disease scleroderma. Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. The structure consists of two domains, with a novel fold in the N-terminal region and a methyltransferase-like domain in the C-terminal region. Mapping temperature-sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structure reveals that many of the mutations cluster in the core of the methyltransferase-like domain.
About this Structure
1FBN is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution., Wang H, Boisvert D, Kim KK, Kim R, Kim SH, EMBO J. 2000 Feb 1;19(3):317-23. PMID:10654930
Page seeded by OCA on Thu Feb 21 12:36:57 2008
Categories: Methanocaldococcus jannaschii | Single protein | BSGC, Berkeley Structural Genomics Center. | Boisvert, D. | Kim, K K. | Kim, R. | Kim, S H. | Wang, H. | Berkeley structural genomics center | Bsgc structure funded by nih | Fibrillarin | Mj proteins | Protein structure initiative | Psi | Ribosomal rna processing | Snornp | Structural genomics
