1o7t
From Proteopedia
(New page: 200px<br /> <applet load="1o7t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o7t, resolution 1.65Å" /> '''METAL NANOCLUSTERS ...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1O7T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]] with HF5, HF3 and PHF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA]]. | + | 1O7T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]] with HF5, HF3 and PHF as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: HF1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7T OCA]]. |
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: periplasmic ferric binding protein]] | [[Category: periplasmic ferric binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:04:18 2007'' |
Revision as of 11:59, 30 October 2007
|
METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.
Overview
Transferrins transport Fe3+ and other metal ions in mononuclear-binding, sites. We present the first evidence that a member of the transferrin, superfamily is able to recognize multi-nuclear oxo-metal clusters, small, mineral fragments that are the most abundant forms of many metals in the, environment. We show that the ferric ion-binding protein from Neisseria, gonorrhoeae (nFbp) readily binds clusters of Fe3+, Ti4+, Zr4+ or Hf4+ in, solution. The 1.7 A resolution crystal structure of Hf-nFbp reveals three, distinct types of clusters in an open, positively charged cleft between, two hinged protein domains. A di-tyrosyl cluster nucleation motif, (Tyr195-Tyr196) is situated at the bottom of this cleft and binds either a, trinuclear oxo-Hf cluster, which is capped by phosphate, or a ... [(full description)]
About this Structure
1O7T is a [Single protein] structure of sequence from [Neisseria gonorrhoeae] with HF5, HF3 and PHF as [ligands]. Structure known Active Site: HF1. Full crystallographic information is available from [OCA].
Reference
A novel protein-mineral interface., Alexeev D, Zhu H, Guo M, Zhong W, Hunter DJ, Yang W, Campopiano DJ, Sadler PJ, Nat Struct Biol. 2003 Apr;10(4):297-302. PMID:12598891
Page seeded by OCA on Tue Oct 30 14:04:18 2007
