1g2i
From Proteopedia
(New page: 200px<br /><applet load="1g2i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g2i, resolution 2.00Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1g2i.gif|left|200px]]<br /><applet load="1g2i" size=" | + | [[Image:1g2i.gif|left|200px]]<br /><applet load="1g2i" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1g2i, resolution 2.00Å" /> | caption="1g2i, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The intracellular protease from Pyrococcus horikoshii (PH1704) and PfpI | + | The intracellular protease from Pyrococcus horikoshii (PH1704) and PfpI from Pyrococcus furiosus are members of a class of intracellular proteases that have no sequence homology to any other known protease family. We report the crystal structure of PH1704 at 2.0-A resolution. The protease is tentatively identified as a cysteine protease based on the presence of cysteine (residue 100) in a nucleophile elbow motif. In the crystal, PH1704 forms a hexameric ring structure, and the active sites are formed at the interfaces between three pairs of monomers. |
==About this Structure== | ==About this Structure== | ||
| - | 1G2I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1G2I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2I OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pyrococcus horikoshii]] | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: BSGC, Berkeley | + | [[Category: BSGC, Berkeley Structural Genomics Center.]] |
[[Category: Choi, I-G.]] | [[Category: Choi, I-G.]] | ||
[[Category: Du, X.]] | [[Category: Du, X.]] | ||
[[Category: Jancarik, J.]] | [[Category: Jancarik, J.]] | ||
[[Category: Kim, R.]] | [[Category: Kim, R.]] | ||
| - | [[Category: Kim, S | + | [[Category: Kim, S H.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: atp-independent intracellular protease]] | [[Category: atp-independent intracellular protease]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:45:21 2008'' |
Revision as of 10:45, 21 February 2008
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CRYSTAL STRUCTURE OF A NOVEL INTRACELLULAR PROTEASE FROM PYROCOCCUS HORIKOSHII AT 2 A RESOLUTION
Overview
The intracellular protease from Pyrococcus horikoshii (PH1704) and PfpI from Pyrococcus furiosus are members of a class of intracellular proteases that have no sequence homology to any other known protease family. We report the crystal structure of PH1704 at 2.0-A resolution. The protease is tentatively identified as a cysteine protease based on the presence of cysteine (residue 100) in a nucleophile elbow motif. In the crystal, PH1704 forms a hexameric ring structure, and the active sites are formed at the interfaces between three pairs of monomers.
About this Structure
1G2I is a Single protein structure of sequence from Pyrococcus horikoshii with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution., Du X, Choi IG, Kim R, Wang W, Jancarik J, Yokota H, Kim SH, Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14079-84. PMID:11114201
Page seeded by OCA on Thu Feb 21 12:45:21 2008
Categories: Pyrococcus horikoshii | Single protein | BSGC, Berkeley Structural Genomics Center. | Choi, I-G. | Du, X. | Jancarik, J. | Kim, R. | Kim, S H. | SO4 | Atp-independent intracellular protease | Berkeley structural genomics center | Bsgc structure funded by nih | Catalytical triad | Cysteine protease | Intracellular protease | Nucleophile elbow | Pfpi | Protease | Protein structure initiative | Psi | Structural genomics
