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2bku
From Proteopedia
(New page: 200px<br /> <applet load="2bku" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bku, resolution 2.70Å" /> '''KAP95P:RANGTP COMPL...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BKU is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ | + | 2BKU is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]] and [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MG and GTP as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 2BKU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb85_1.html Importins]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BKU OCA]]. |
==Reference== | ==Reference== | ||
Structural basis for nuclear import complex dissociation by RanGTP., Lee SJ, Matsuura Y, Liu SM, Stewart M, Nature. 2005 Jun 2;435(7042):693-6. Epub 2005 May 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15864302 15864302] | Structural basis for nuclear import complex dissociation by RanGTP., Lee SJ, Matsuura Y, Liu SM, Stewart M, Nature. 2005 Jun 2;435(7042):693-6. Epub 2005 May 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15864302 15864302] | ||
| - | [[Category: Canis familiaris]] | + | [[Category: Canis lupus familiaris]] |
[[Category: Importins]] | [[Category: Importins]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: rangtp]] | [[Category: rangtp]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:06:41 2007'' |
Revision as of 12:01, 30 October 2007
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KAP95P:RANGTP COMPLEX
Overview
Nuclear protein import is mediated mainly by the transport factor, importin-beta that binds cytoplasmic cargo, most often via the, importin-alpha adaptor, and then transports it through nuclear pore, complexes. This active transport is driven by disassembly of the import, complex by nuclear RanGTP. The switch I and II loops of Ran change, conformation with nucleotide state, and regulate its interactions with, nuclear trafficking components. Importin-beta consists of 19 HEAT repeats, that are based on a pair of antiparallel alpha-helices (referred to as the, A- and B-helices). The HEAT repeats stack to yield two C-shaped arches, linked together to form a helicoidal molecule that has considerable, conformational flexibility. Here we present the structure of full-length, yeast importin-beta ... [(full description)]
About this Structure
2BKU is a [Protein complex] structure of sequences from [Canis lupus familiaris] and [Saccharomyces cerevisiae] with MG and GTP as [ligands]. The following page contains interesting information on the relation of 2BKU with [Importins]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis for nuclear import complex dissociation by RanGTP., Lee SJ, Matsuura Y, Liu SM, Stewart M, Nature. 2005 Jun 2;435(7042):693-6. Epub 2005 May 1. PMID:15864302
Page seeded by OCA on Tue Oct 30 14:06:41 2007
