2f3f

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Revision as of 07:26, 27 July 2012

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Template:STRUCTURE 2f3f

Contents 1 Crystal Structure of the Bace complex with BDF488, a macrocyclic inhibitor 2 About this Structure 3 See Also 4 Reference

Crystal Structure of the Bace complex with BDF488, a macrocyclic inhibitor

Template:ABSTRACT PUBMED 16854060

About this Structure

2f3f is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Hanessian S, Yang G, Rondeau JM, Neumann U, Betschart C, Tintelnot-Blomley M. Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). J Med Chem. 2006 Jul 27;49(15):4544-67. PMID:16854060 doi:10.1021/jm060154a