1af8
From Proteopedia
(New page: 200px<br /> <applet load="1af8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1af8" /> '''ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AF8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AF8 OCA]]. | + | 1AF8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]]. Structure known Active Site: S42. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AF8 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: streptomyces]] | [[Category: streptomyces]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:11:41 2007'' |
Revision as of 12:06, 30 October 2007
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ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES
Overview
The solution structure of the actinorhodin acyl carrier protein (act, apo-ACP) from the polyketide synthase (PKS) of Streptomyces coelicolor, A3(2) has been determined using 1H NMR spectroscopy, representing the, first polyketide synthase component for which detailed structural, information has been obtained. Twenty-four structures were generated by, simulated annealing, employing 699 distance restraints and 94 dihedral, angle restraints. The structure is composed, principally, of three major, helices (1, 2, and 4), a shorter helix (3) and a large loop region, separating helices 1 and 2. The structure is well-defined, except for a, portion of the loop region (residues 18-29), the N-terminus (1-4), and a, short stretch (57-61) in the loop connecting helices 2 and 3. The RMS, distribution ... [(full description)]
About this Structure
1AF8 is a [Single protein] structure of sequence from [Streptomyces coelicolor]. Structure known Active Site: S42. Full crystallographic information is available from [OCA].
Reference
Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)., Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ, Biochemistry. 1997 May 20;36(20):6000-8. PMID:9166770
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