2c1v
From Proteopedia
(New page: 200px<br /> <applet load="2c1v" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c1v, resolution 1.20Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C1V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus]] with CA, HEC and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1V OCA]]. | + | 2C1V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus]] with CA, HEC and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1V OCA]]. |
==Reference== | ==Reference== | ||
Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus., Echalier A, Goodhew CF, Pettigrew GW, Fulop V, Structure. 2006 Jan;14(1):107-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16407070 16407070] | Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus., Echalier A, Goodhew CF, Pettigrew GW, Fulop V, Structure. 2006 Jan;14(1):107-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16407070 16407070] | ||
| + | [[Category: Cytochrome-c peroxidase]] | ||
[[Category: Paracoccus pantotrophus]] | [[Category: Paracoccus pantotrophus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:12:10 2007'' |
Revision as of 12:07, 30 October 2007
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CRYSTAL STRUCTURE OF THE DI-HAEM CYTOCHROME C PEROXIDASE FROM PARACOCCUS PANTOTROPHUS- MIXED VALENCE FORM
Overview
Bacterial cytochrome c peroxidases contain an electron transferring (E), heme domain and a peroxidatic (P) heme domain. All but one of these, enzymes are isolated in an inactive oxidized state and require reduction, of the E heme by a small redox donor protein in order to activate the P, heme. Here we present the structures of the inactive oxidized and active, mixed valence enzyme from Paracoccus pantotrophus. Chain flexibility in, the former, as expressed by the crystallographic temperature factors, is, strikingly distributed in certain loop regions, and these coincide with, the regions of conformational change that occur in forming the active, mixed valence enzyme. On the basis of these changes, we postulate a series, of events that occur to link the trigger of the electron entering the ... [(full description)]
About this Structure
2C1V is a [Single protein] structure of sequence from [Paracoccus pantotrophus] with CA, HEC and EDO as [ligands]. Active as [Cytochrome-c peroxidase], with EC number [1.11.1.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Activation and catalysis of the di-heme cytochrome c peroxidase from Paracoccus pantotrophus., Echalier A, Goodhew CF, Pettigrew GW, Fulop V, Structure. 2006 Jan;14(1):107-17. PMID:16407070
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