2c1h
From Proteopedia
(New page: 200px<br /> <applet load="2c1h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c1h, resolution 2.60Å" /> '''THE X-RAY STRUCTURE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C1H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2C1H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Prosthecochloris_vibrioformis Prosthecochloris vibrioformis]] with MG and DSB as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C1H OCA]]. |
==Reference== | ==Reference== | ||
Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor., Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005, Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16304458 16304458] | Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor., Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005, Nov 19. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16304458 16304458] | ||
| - | [[Category: | + | [[Category: Porphobilinogen synthase]] |
| + | [[Category: Prosthecochloris vibrioformis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beale, S.]] | [[Category: Beale, S.]] | ||
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[[Category: porphyrin biosynthesis]] | [[Category: porphyrin biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:12:42 2007'' |
Revision as of 12:07, 30 October 2007
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THE X-RAY STRUCTURE OF CHLOROBIUM VIBRIOFORME 5-AMINOLAEVULINIC ACID DEHYDRATASE COMPLEXED WITH A DIACID INHIBITOR
Overview
The structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase, (ALAD) complexed with the irreversible inhibitor 4,7-dioxosebacic acid has, been solved. The inhibitor binds by forming Schiff-base linkages with, lysines 200 and 253 at the active site. The structure reported here, provides a definition of the interactions made by both of the substrate, molecules (A-side and P-side substrates) with the C. vibrioforme ALAD and, is compared and contrasted with structures of the same inhibitor bound to, Escherichia coli and yeast ALAD. The structure suggests why, 4,7-dioxosebacic acid is a better inhibitor of the zinc-dependent ALADs, than of the zinc-independent ALADs.
About this Structure
2C1H is a [Single protein] structure of sequence from [Prosthecochloris vibrioformis] with MG and DSB as [ligands]. Active as [Porphobilinogen synthase], with EC number [4.2.1.24]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor., Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005, Nov 19. PMID:16304458
Page seeded by OCA on Tue Oct 30 14:12:42 2007
Categories: Porphobilinogen synthase | Prosthecochloris vibrioformis | Single protein | Beale, S. | Beaven, G. | Coates, L. | Cooper, J.B. | Erskine, P.T. | Shoolingin-Jordan, P.M. | Wood, S.P. | DSB | MG | 5-aminolaevulinic acid dehydratase | Alad | Heme biosynthesis | Lyase | Magnesium | Porphyrin biosynthesis
