Cholinesterase
From Proteopedia
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They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE). | They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE). | ||
AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form. | AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form. | ||
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| + | <Structure load='1b41' size='400' frame='true' align='right' caption='human acetylcholinesterase complex with fasciculin-II, [[1b41]]'/> | ||
<scene name='Cholinesterase/Human_acetylcholinesterase/1'> | <scene name='Cholinesterase/Human_acetylcholinesterase/1'> | ||
Revision as of 09:35, 31 July 2012
Cholinesterase belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.
They are mainly of two types, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.
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Michal Harel, Joel L. Sussman, Lakshmi Venkatachalam, Alexander Berchansky
