1hzi

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(New page: 200px<br /> <applet load="1hzi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hzi, resolution 2.05&Aring;" /> '''INTERLEUKIN-4 MUTAN...)
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'''INTERLEUKIN-4 MUTANT E9A'''<br />
'''INTERLEUKIN-4 MUTANT E9A'''<br />
==Overview==
==Overview==
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Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell, differentiation and class switching of B cells. It therefore plays a, central role in the development of allergies and asthma. An IL-4 variant, in which Glu9 was mutated to alanine shows an 800-fold drop in binding, affinity towards its high-affinity receptor chain. As shown by surface, plasmon resonance measurements, this mostly arises from a decreased, association rate. Here, the crystal structure of this mutant is reported., It reveals that the protein has a virtually identical structure to the, wild type, showing that the unusual behaviour of the mutated protein is, not a consequence of misfolding. The possibility that polar interactions, in the encounter complex have a steering effect is discussed.
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Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards its high-affinity receptor chain. As shown by surface plasmon resonance measurements, this mostly arises from a decreased association rate. Here, the crystal structure of this mutant is reported. It reveals that the protein has a virtually identical structure to the wild type, showing that the unusual behaviour of the mutated protein is not a consequence of misfolding. The possibility that polar interactions in the encounter complex have a steering effect is discussed.
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1HZI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HZI OCA].
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1HZI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZI OCA].
==Reference==
==Reference==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Dreyer, M.K.]]
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[[Category: Dreyer, M K.]]
[[Category: Hulsmeyer, M.]]
[[Category: Hulsmeyer, M.]]
[[Category: Scheufler, C.]]
[[Category: Scheufler, C.]]
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[[Category: il-4]]
[[Category: il-4]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:24:35 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:22 2008''

Revision as of 11:06, 21 February 2008

Image:1hzi.gif

1hzi, resolution 2.05Å

Drag the structure with the mouse to rotate

INTERLEUKIN-4 MUTANT E9A

Contents

Overview

Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards its high-affinity receptor chain. As shown by surface plasmon resonance measurements, this mostly arises from a decreased association rate. Here, the crystal structure of this mutant is reported. It reveals that the protein has a virtually identical structure to the wild type, showing that the unusual behaviour of the mutated protein is not a consequence of misfolding. The possibility that polar interactions in the encounter complex have a steering effect is discussed.

Disease

Known diseases associated with this structure: AIDS, slow progression to OMIM:[147781], Atopy, susceptibility to OMIM:[147781]

About this Structure

1HZI is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation., Hulsmeyer M, Scheufler C, Dreyer MK, Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1334-6. Epub 2001, Aug 23. PMID:11526337

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