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1iiu

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(New page: 200px<br /><applet load="1iiu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iiu, resolution 2.50&Aring;" /> '''Chicken plasma retin...)
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[[Image:1iiu.jpg|left|200px]]<br /><applet load="1iiu" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1iiu.jpg|left|200px]]<br /><applet load="1iiu" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1iiu, resolution 2.50&Aring;" />
caption="1iiu, resolution 2.50&Aring;" />
'''Chicken plasma retinol-binding protein (RBP)'''<br />
'''Chicken plasma retinol-binding protein (RBP)'''<br />
==Overview==
==Overview==
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The crystal structure of the specific carrier of retinol (retinol-binding, protein, RBP) purified from chicken plasma has been determined (space, group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and, one protein molecule in the asymmetric unit). Despite being obtained from, a species phylogenetically distant from mammals, chicken holoRBP has an, overall structure that closely resembles the previously determined, structures of mammalian holoRBPs. The lack in chicken RBP of eight, carboxy-terminal amino acid residues characteristic of mammalian RBPs does, not significantly affect the protein structure. A distinctive feature of, the avian protein is a better definition of the loop 63-67, close to the, opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.
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The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.
==About this Structure==
==About this Structure==
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1IIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CD and RTL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IIU OCA].
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1IIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=RTL:'>RTL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIU OCA].
==Reference==
==Reference==
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[[Category: retinol]]
[[Category: retinol]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:25:57 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:22 2008''

Revision as of 11:12, 21 February 2008

Image:1iiu.jpg

1iiu, resolution 2.50Å

Drag the structure with the mouse to rotate

Chicken plasma retinol-binding protein (RBP)

Overview

The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.

About this Structure

1IIU is a Single protein structure of sequence from Gallus gallus with and as ligands. Full crystallographic information is available from OCA.

Reference

Structure of chicken plasma retinol-binding protein., Zanotti G, Calderone V, Beda M, Malpeli G, Folli C, Berni R, Biochim Biophys Acta. 2001 Nov 26;1550(1):64-9. PMID:11738088

Page seeded by OCA on Thu Feb 21 13:12:22 2008

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