1ik0
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable | + | Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic target. The high-resolution solution structure of human IL-13 has been determined by multidimensional NMR. The resulting structure is consistent with previous short-chain left-handed four-helix bundles, where a significant similarity in the folding topology between IL-13 and IL-4 was observed. IL-13 shares a significant overlap in biological function with IL-4, a result of the common alpha chain component (IL-4Ralpha) in their respective receptors. Based on the available structural and mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodimer is proposed for IL-13. |
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Diblasio, E.]] | [[Category: Diblasio, E.]] | ||
| - | [[Category: Moy, F | + | [[Category: Moy, F J.]] |
[[Category: Powers, R.]] | [[Category: Powers, R.]] | ||
[[Category: Wilhelm, J.]] | [[Category: Wilhelm, J.]] | ||
[[Category: left-handed four-helix bundle]] | [[Category: left-handed four-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:12:39 2008'' |
Revision as of 11:12, 21 February 2008
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Solution Structure of Human IL-13
Contents |
Overview
Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic target. The high-resolution solution structure of human IL-13 has been determined by multidimensional NMR. The resulting structure is consistent with previous short-chain left-handed four-helix bundles, where a significant similarity in the folding topology between IL-13 and IL-4 was observed. IL-13 shares a significant overlap in biological function with IL-4, a result of the common alpha chain component (IL-4Ralpha) in their respective receptors. Based on the available structural and mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for forming the signaling heterodimer is proposed for IL-13.
Disease
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]
About this Structure
1IK0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human IL-13 and implication for receptor binding., Moy FJ, Diblasio E, Wilhelm J, Powers R, J Mol Biol. 2001 Jun 29;310(1):219-30. PMID:11419948
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