2br2
From Proteopedia
(New page: 200px<br /> <applet load="2br2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2br2, resolution 2.80Å" /> '''RNASE PH CORE OF TH...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2BR2 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BR2 OCA]]. | + | 2BR2 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BR2 OCA]]. |
==Reference== | ==Reference== | ||
| Line 26: | Line 26: | ||
[[Category: rnase ph]] | [[Category: rnase ph]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:24:45 2007'' |
Revision as of 12:20, 30 October 2007
|
RNASE PH CORE OF THE ARCHAEAL EXOSOME
Overview
The exosome is a 3' --> 5' exoribonuclease complex involved in RNA, processing. We report the crystal structure of the RNase PH core complex, of the Sulfolobus solfataricus exosome determined at a resolution of 2.8, A. The structure reveals a hexameric ring-like arrangement of three, Rrp41-Rrp42 heterodimers, where both subunits adopt the RNase PH fold, common to phosphorolytic exoribonucleases. Structure-guided mutagenesis, reveals that the activity of the complex resides within the active sites, of the Rrp41 subunits, all three of which face the same side of the, hexameric structure. The Rrp42 subunit is inactive but contributes to the, structuring of the Rrp41 active site. The high sequence similarity of this, archaeal exosome to eukaryotic exosomes and its high structural ... [(full description)]
About this Structure
2BR2 is a [Protein complex] structure of sequences from [Sulfolobus solfataricus] with CL as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The archaeal exosome core is a hexameric ring structure with three catalytic subunits., Lorentzen E, Walter P, Fribourg S, Evguenieva-Hackenberg E, Klug G, Conti E, Nat Struct Mol Biol. 2005 Jul;12(7):575-81. Epub 2005 Jun 12. PMID:15951817
Page seeded by OCA on Tue Oct 30 14:24:45 2007
