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1jig
From Proteopedia
(New page: 200px<br /><applet load="1jig" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jig, resolution 1.46Å" /> '''Dlp-2 from Bacillus ...) |
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| - | [[Image:1jig.jpg|left|200px]]<br /><applet load="1jig" size=" | + | [[Image:1jig.jpg|left|200px]]<br /><applet load="1jig" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jig, resolution 1.46Å" /> | caption="1jig, resolution 1.46Å" /> | ||
'''Dlp-2 from Bacillus anthracis'''<br /> | '''Dlp-2 from Bacillus anthracis'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Bacillus anthracis is currently under intense investigation due to its | + | Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth. |
==About this Structure== | ==About this Structure== | ||
| - | 1JIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with FE as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis] with <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JIG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Battistutta, R.]] | [[Category: Battistutta, R.]] | ||
| - | [[Category: Dundon, W | + | [[Category: Dundon, W G.]] |
[[Category: Montecucco, C.]] | [[Category: Montecucco, C.]] | ||
[[Category: Papinutto, E.]] | [[Category: Papinutto, E.]] | ||
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[[Category: four-helix bundle]] | [[Category: four-helix bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:59 2008'' |
Revision as of 11:23, 21 February 2008
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Dlp-2 from Bacillus anthracis
Overview
Bacillus anthracis is currently under intense investigation due to its primary importance as a human pathogen. Particularly important is the development of novel anti-anthrax vaccines, devoid of the current side effects. A novel class of immunogenic bacterial proteins consists of dodecamers homologous to the DNA-binding protein of Escherichia coli (Dps). Two Dps homologous genes are present in the B. anthracis genome. The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been determined and are presented here. They are sphere-like proteins with an internal cavity. We also show that they act as ferritins and are thus involved in iron uptake and regulation, a fundamental function during bacterial growth.
About this Structure
1JIG is a Single protein structure of sequence from Bacillus anthracis with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:11836250
Page seeded by OCA on Thu Feb 21 13:22:59 2008
