1ji7
From Proteopedia
(New page: 200px<br /> <applet load="1ji7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ji7, resolution 1.45Å" /> '''Crystal Structure o...) |
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| - | [[Image:1ji7.gif|left|200px]]<br /> | + | [[Image:1ji7.gif|left|200px]]<br /><applet load="1ji7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ji7" size=" | + | |
caption="1ji7, resolution 1.45Å" /> | caption="1ji7, resolution 1.45Å" /> | ||
'''Crystal Structure of TEL SAM Polymer'''<br /> | '''Crystal Structure of TEL SAM Polymer'''<br /> | ||
==Overview== | ==Overview== | ||
| - | TEL is a transcriptional repressor that is a frequent target of | + | TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bowie, J | + | [[Category: Bowie, J U.]] |
[[Category: Faham, S.]] | [[Category: Faham, S.]] | ||
[[Category: Gingery, M.]] | [[Category: Gingery, M.]] | ||
| - | [[Category: Kim, C | + | [[Category: Kim, C A.]] |
[[Category: Kim, W.]] | [[Category: Kim, W.]] | ||
| - | [[Category: Phillips, M | + | [[Category: Phillips, M L.]] |
| - | [[Category: Robinson, M | + | [[Category: Robinson, M A.]] |
| - | [[Category: Tran, H | + | [[Category: Tran, H H.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: helical polymer]] | [[Category: helical polymer]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:56 2008'' |
Revision as of 11:23, 21 February 2008
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Crystal Structure of TEL SAM Polymer
Contents |
Overview
TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.
Disease
Known diseases associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]
About this Structure
1JI7 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520
Page seeded by OCA on Thu Feb 21 13:22:56 2008
Categories: Homo sapiens | Single protein | Bowie, J U. | Faham, S. | Gingery, M. | Kim, C A. | Kim, W. | Phillips, M L. | Robinson, M A. | Tran, H H. | SO4 | Helical polymer
