1jjo
From Proteopedia
(New page: 200px<br /><applet load="1jjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jjo, resolution 3.06Å" /> '''Crystal Structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size=" | + | [[Image:1jjo.gif|left|200px]]<br /><applet load="1jjo" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jjo, resolution 3.06Å" /> | caption="1jjo, resolution 3.06Å" /> | ||
'''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''<br /> | '''Crystal Structure of Mouse Neuroserpin (Cleaved form)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The protease inhibitor neuroserpin regulates the development of the | + | The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin. |
==About this Structure== | ==About this Structure== | ||
| - | 1JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1JJO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JJO OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Briand, C.]] | [[Category: Briand, C.]] | ||
| - | [[Category: Gruetter, M | + | [[Category: Gruetter, M G.]] |
| - | [[Category: Kozlov, S | + | [[Category: Kozlov, S V.]] |
[[Category: Sonderegger, P.]] | [[Category: Sonderegger, P.]] | ||
[[Category: neuronal serpin]] | [[Category: neuronal serpin]] | ||
| Line 21: | Line 21: | ||
[[Category: serpin]] | [[Category: serpin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:23:22 2008'' |
Revision as of 11:23, 21 February 2008
|
Crystal Structure of Mouse Neuroserpin (Cleaved form)
Overview
The protease inhibitor neuroserpin regulates the development of the nervous system and its plasticity in the adult. Neuroserpins carrying the Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe here the structure of wild-type neuroserpin in a cleaved form. The structure provides a basis to understand the role of the mutations in the polymerization process. We propose that these mutations could delay the insertion of the reactive center loop into the central beta-sheet A, an essential step in the inhibition and possibly in the polymerization of neuroserpin.
About this Structure
1JJO is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease., Briand C, Kozlov SV, Sonderegger P, Grutter MG, FEBS Lett. 2001 Sep 7;505(1):18-22. PMID:11557034
Page seeded by OCA on Thu Feb 21 13:23:22 2008
