1jwt
From Proteopedia
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
| - | Peptidomimetic inhibitors of thrombin lacking the important | + | Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo. |
==Disease== | ==Disease== | ||
| Line 18: | Line 18: | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Bachand, B.]] | [[Category: Bachand, B.]] | ||
| - | [[Category: Edmunds, J | + | [[Category: Edmunds, J J.]] |
[[Category: Leblond, L.]] | [[Category: Leblond, L.]] | ||
[[Category: Levesque, S.]] | [[Category: Levesque, S.]] | ||
[[Category: Preville, P.]] | [[Category: Preville, P.]] | ||
| - | [[Category: Rubin, J | + | [[Category: Rubin, J R.]] |
| - | [[Category: Siddiqui, M | + | [[Category: Siddiqui, M A.]] |
[[Category: St-Denis, Y.]] | [[Category: St-Denis, Y.]] | ||
| - | [[Category: Winocour, P | + | [[Category: Winocour, P D.]] |
[[Category: BLI]] | [[Category: BLI]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:43 2008'' |
Revision as of 11:27, 21 February 2008
|
CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR
Contents |
Overview
Peptidomimetic inhibitors of thrombin lacking the important Ser195-carbonyl interaction have been prepared. The binding energy lost after the removal of the activated carbonyl was recaptured through a series of modifications of the P1 residues of the bicyclic lactam inhibitors. Selected substituted compounds displayed useful pharmacological profiles both in vitro and in vivo.
Disease
Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
1JWT is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
Reference
Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues., Levesque S, St-Denis Y, Bachand B, Preville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA, Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. PMID:11720865
Page seeded by OCA on Thu Feb 21 13:27:43 2008
