1jzn

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(New page: 200px<br /><applet load="1jzn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jzn, resolution 2.20&Aring;" /> '''crystal structure of...)
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[[Image:1jzn.gif|left|200px]]<br /><applet load="1jzn" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1jzn.gif|left|200px]]<br /><applet load="1jzn" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1jzn, resolution 2.20&Aring;" />
caption="1jzn, resolution 2.20&Aring;" />
'''crystal structure of a galactose-specific C-type lectin'''<br />
'''crystal structure of a galactose-specific C-type lectin'''<br />
==Overview==
==Overview==
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake, (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The, X-ray crystal structure of RSL, in complex with lactose and, thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a, decameric protein composed of two 5-fold symmetric pentamers arranged in a, staggered, back-to-back orientation. Each monomer corresponds to a single, canonical C-type lectin carbohydrate recognition domain devoid of, accessory domains and is disulfide-bonded to a monomer in the other, pentamer. The structure is the first example of that of a carbohydrate, complex of a vertebrate galactose-specific C-type lectin. The 10, carbohydrate-binding sites, located on the rim of the decamer, suggest a, role for multivalent interactions and a mechanism for RSL's ability to, promote receptor cross-linking and cell aggregation.
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
==About this Structure==
==About this Structure==
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1JZN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with CA, NA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JZN OCA].
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1JZN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZN OCA].
==Reference==
==Reference==
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[[Category: Hirama, T.]]
[[Category: Hirama, T.]]
[[Category: Nagar, B.]]
[[Category: Nagar, B.]]
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[[Category: Rini, J.M.]]
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[[Category: Rini, J M.]]
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[[Category: Walker, J.R.]]
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[[Category: Walker, J R.]]
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[[Category: Young, N.M.]]
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[[Category: Young, N M.]]
[[Category: CA]]
[[Category: CA]]
[[Category: CL]]
[[Category: CL]]
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[[Category: protein-disaccharide complex]]
[[Category: protein-disaccharide complex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:43:26 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:28:28 2008''

Revision as of 11:28, 21 February 2008

Image:1jzn.gif

1jzn, resolution 2.20Å

Drag the structure with the mouse to rotate

crystal structure of a galactose-specific C-type lectin

Overview

Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.

About this Structure

1JZN is a Single protein structure of sequence from Crotalus atrox with , and as ligands. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685

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