1k3v
From Proteopedia
(New page: 200px<br /><applet load="1k3v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k3v, resolution 3.5Å" /> '''Porcine Parvovirus Ca...) |
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| - | [[Image:1k3v.jpg|left|200px]]<br /><applet load="1k3v" size=" | + | [[Image:1k3v.jpg|left|200px]]<br /><applet load="1k3v" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1k3v, resolution 3.5Å" /> | caption="1k3v, resolution 3.5Å" /> | ||
'''Porcine Parvovirus Capsid'''<br /> | '''Porcine Parvovirus Capsid'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of baculovirus-expressed porcine parvovirus (PPV) capsids | + | The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions. |
==About this Structure== | ==About this Structure== | ||
| - | 1K3V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Porcine_parvovirus Porcine parvovirus]. Full crystallographic information is available from [http:// | + | 1K3V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Porcine_parvovirus Porcine parvovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3V OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hebert, B.]] | [[Category: Hebert, B.]] | ||
| - | [[Category: Parrish, C | + | [[Category: Parrish, C R.]] |
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
| - | [[Category: Simpson, A | + | [[Category: Simpson, A A.]] |
| - | [[Category: Sullivan, G | + | [[Category: Sullivan, G M.]] |
[[Category: Tijssen, P.]] | [[Category: Tijssen, P.]] | ||
[[Category: Zadori, Z.]] | [[Category: Zadori, Z.]] | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:29:50 2008'' |
Revision as of 11:29, 21 February 2008
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Porcine Parvovirus Capsid
Overview
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions.
About this Structure
1K3V is a Single protein structure of sequence from Porcine parvovirus. Full crystallographic information is available from OCA.
Reference
The structure of porcine parvovirus: comparison with related viruses., Simpson AA, Hebert B, Sullivan GM, Parrish CR, Zadori Z, Tijssen P, Rossmann MG, J Mol Biol. 2002 Feb 1;315(5):1189-98. PMID:11827486
Page seeded by OCA on Thu Feb 21 13:29:50 2008
