Fragment-Based Drug Discovery

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—== Paclitaxel in Apoptosis ==
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== Paclitaxel in Apoptosis ==
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<StructureSection load='1ysi' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ysi]])' scene=''>
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<StructureSection load='1ysi' size='500' side='right' caption='Structure of Bcl-xl/Paclitaxel complex (PDB entry [[1ysi]])' scene=''>
This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets.
This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets.

Revision as of 17:58, 1 October 2012

Paclitaxel in Apoptosis

Structure of Bcl-xl/Paclitaxel complex (PDB entry 1ysi)

Drag the structure with the mouse to rotate

References

  1. ↑ Oltersdorf T., Elmore S.W., Shoemaker A.R. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Vol 435|2 June 2005|doi:10.1038/nature03579

Proteopedia Page Contributors and Editors (what is this?)

Justin Weekley, Arthur Cox, Jaime Prilusky

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