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Fragment-Based Drug Discovery
From Proteopedia
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== Paclitaxel in Apoptosis == | == Paclitaxel in Apoptosis == | ||
<StructureSection load='1ysi' size='500' side='right' caption='Structure of Bcl-xl/Paclitaxel complex (PDB entry [[1ysi]])' scene=''> | <StructureSection load='1ysi' size='500' side='right' caption='Structure of Bcl-xl/Paclitaxel complex (PDB entry [[1ysi]])' scene=''> | ||
| - | This represents the binding of the anti-cancer drug, paclitaxel, to the anti-apoptotic protein, Bcl-xl. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets. | + | This represents the binding of the anti-cancer drug, <scene name='Sandbox_reserved_394/Paclitaxel/1'>paclitaxel</scene>, to the anti-apoptotic protein, <scene name='Sandbox_reserved_394/Bcl-xl/1'>Bcl-xl</scene>. The protein includes seven <scene name='Sandbox_reserved_394/Alpha_helices/1'>alpha helices</scene> and no beta sheets. |
Revision as of 18:01, 1 October 2012
Paclitaxel in Apoptosis
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References
- ↑ Oltersdorf T., Elmore S.W., Shoemaker A.R. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Vol 435|2 June 2005|doi:10.1038/nature03579
