1ken
From Proteopedia
(New page: 200px<br /> <applet load="1ken" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ken, resolution 3.50Å" /> '''INFLUENZA VIRUS HEM...) |
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| - | [[Image:1ken.gif|left|200px]]<br /> | + | [[Image:1ken.gif|left|200px]]<br /><applet load="1ken" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ken" size=" | + | |
caption="1ken, resolution 3.50Å" /> | caption="1ken, resolution 3.50Å" /> | ||
'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''<br /> | '''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the structure of a complex of influenza hemagglutinin | + | We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition. |
==About this Structure== | ==About this Structure== | ||
| - | 1KEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1KEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KEN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Barbey-Martin, C.]] | [[Category: Barbey-Martin, C.]] | ||
[[Category: Bizebard, T.]] | [[Category: Bizebard, T.]] | ||
| - | [[Category: Calder, L | + | [[Category: Calder, L J.]] |
[[Category: Gigant, B.]] | [[Category: Gigant, B.]] | ||
[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
| - | [[Category: Wharto, S | + | [[Category: Wharto, S A.]] |
[[Category: envelope protein]] | [[Category: envelope protein]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: hemagglutinin]] | [[Category: hemagglutinin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:33:15 2008'' |
Revision as of 11:33, 21 February 2008
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INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION
Overview
We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.
About this Structure
1KEN is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.
Reference
An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:11886266
Page seeded by OCA on Thu Feb 21 13:33:15 2008
