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4flh

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[[Image:4flh.jpg|left|200px]]
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{{STRUCTURE_4flh| PDB=4flh | SCENE= }}
{{STRUCTURE_4flh| PDB=4flh | SCENE= }}

Revision as of 06:36, 3 October 2012

Image:4flh.png

Template:STRUCTURE 4flh

Crystal structure of human PI3K-gamma in complex with AMG511

Template:ABSTRACT PUBMED 22897589

About this Structure

4flh is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Norman MH, Liu L, Andrews K, Bo Y, Booker S, Caenepeel S, Cee VJ, D'Angelo ND, Freeman DJ, Herberich B, Hong FT, Jackson C, Jiang J, Lannman B, McCarter JD, Mullady E, Nishimura N, Pettus LH, Reed A, San Miguel T, Smith A, Stec MM, Tadesse S, Tasker A, Aidasani D, Zhu S, Subramanian R, Tamayo NA, Wang L, Whittington DA, Wu B, Wu T, Wurz RP, Yang K, Zalameda L, Zhang N, Hughes P. Selective Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors: Optimization of a Series of Pyridyl-triazines Leading to the Identification of a Clinical Candidate, AMG 511. J Med Chem. 2012 Aug 16. PMID:22897589 doi:10.1021/jm300846z

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OCA

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