Growth factor receptor-bound protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
== Your Heading Here (maybe something like 'Structure') == | == Your Heading Here (maybe something like 'Structure') == | ||
| - | <StructureSection load=' | + | <StructureSection load='1cj1' size='400' side='right' caption='Structure of human Grb2 SH2 domain complex with phosphotyrosyl derivative (PDB entry [[1cj1]])' scene=''> |
'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. | '''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. | ||
| Line 10: | Line 10: | ||
[[2vvk]], [[2vwf]], [[2w0z]] - hGRB2 SH3 domain<br /> | [[2vvk]], [[2vwf]], [[2w0z]] - hGRB2 SH3 domain<br /> | ||
[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1qg1]], [[1jyq]], [[1jyr]], [[2aob]], [[2h5k]], [[2huw]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8n]], [[3s8o]] - hGRB2 SH2 domain + phosphotyrosyl peptide<br /> | [[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1qg1]], [[1jyq]], [[1jyr]], [[2aob]], [[2h5k]], [[2huw]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8n]], [[3s8o]] - hGRB2 SH2 domain + phosphotyrosyl peptide<br /> | ||
| - | [[1x0n]] - hGRB2 SH2 domain + inhibitor<br /> | + | [[1x0n]] - hGRB2 SH2 domain + inhibitor - NMR<br /> |
[[1cj1]] - hGRB2 SH2 domain + phosphotyrosyl derivative<br /> | [[1cj1]] - hGRB2 SH2 domain + phosphotyrosyl derivative<br /> | ||
[[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br /> | [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]], [[1aze]] - GRB2 SH3 domain + SOS-1 peptide – NMR<br /> | ||
[[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR | [[1io6]], [[1h3h]] - GRB2 SH3 domain + ligand peptide – NMR | ||
Revision as of 11:56, 11 October 2012
Your Heading Here (maybe something like 'Structure')
| |||||||||||
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
