Glucosamine 6-phosphate synthase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1moq' size='400' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate (PDB entry 1moq)' scene=''> '''Gluco...) |
|||
| Line 1: | Line 1: | ||
| - | + | <StructureSection load='1moq' size='400' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate, sulfate and Na+ (PDB entry [[1moq]])' scene=''> | |
| - | <StructureSection load='1moq' size='400' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate (PDB entry [[1moq]])' scene=''> | + | |
'''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). | ||
Revision as of 09:41, 15 October 2012
| |||||||||||
