Death-associated protein kinase

Death-associated protein kinase (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions. DAPK1 is a positive mediator of γ-interferon induced programmed cell death. DAPK2 is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. DAPK3 or zipper-interacting protein kinase is involved in the regulation of apoptosis.

3D structures of death-associated protein kinase

Death-associated protein kinase 1

1ig1, 1jkk, 3f5g, 3f5u – hDAPK catalytic domain + cation + nucleotide – human
3gu5, 3gu7 - hDAPK catalytic domain (mutant) + cation + nucleotide
3eh9, 1jkl, 3eha, 3zxt - hDAPK catalytic domain + nucleotide
3dfc, 3gu4, 3gu6, 3gu8, 3gub - hDAPK catalytic domain (mutant) + nucleotide
1jks, 1jkt, 1zws, 2w4k, 2xzs, 2y0a, 2y4p – hDAPK catalytic domain
1wmk, 2a27, 3dgk - hDAPK catalytic domain (mutant)
2xuu - hDAPK catalytic and autoinhibitory domains (mutant)
1p4f, 1wvw, 1wvx, 1wvy, 2yak – hDAPK catalytic domain + inhibitor
2x0g - hDAPK catalytic domain + calmodulin

Death-associated protein kinase 2

2a2a, 2w4j – hDAPK catalytic domain
1z9x - hDAPK catalytic domain (mutant)
2cke - hDAPK catalytic domain + inhibitor
2ya9 – mDAPK catalytic and autoinhibitory domains – mouse
2yaa, 2yab - mDAPK catalytic and autoinhibitory domains + nucleotide

Death-associated protein kinase 3

1yrp - hDAPK catalytic domain
2j90, 3bhy, 3bqr - hDAPK catalytic domain + inhibitor