GMP synthase (GMPS) catalyzes the conversion of xantosine 5’-phosphate, ATP, glutamine and water to glutamate, GMP, AMP and diphosphate. GMPS is active in purine and glutamate metabolism.
3D structures of GMP synthase
1wl8, 2d7j – PhGMPS subunit A – Pyrococcus horikoshii
2dpl, 3a4i - PhGMPS subunit B
2yw7 – TtGMPS – Thermus thermophilus
3tqi – GMPS – Coxiella burnetii
1kxj – TmGMPS – Thermotoga maritima
2vpi – hGMPS glutaminase domain – human
2vxo - hGMPS + xantosine 5’-phosphate
2ywc – TtGMPS + xantosine 5’-phosphate
2iss – TmGMPS subunit PDXT + PLP biosynthesis lyase PDXS
1gpm – GMPS + pyrophosphate + AMP – Escherichia coli
