1lev
From Proteopedia
(New page: 200px<br /><applet load="1lev" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lev, resolution 2.15Å" /> '''PORCINE KIDNEY FRUCT...) |
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| - | [[Image:1lev.jpg|left|200px]]<br /><applet load="1lev" size=" | + | [[Image:1lev.jpg|left|200px]]<br /><applet load="1lev" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1lev, resolution 2.15Å" /> | caption="1lev, resolution 2.15Å" /> | ||
'''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''<br /> | '''PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | 3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to | + | 3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design. |
==About this Structure== | ==About this Structure== | ||
| - | 1LEV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with F6P, MN and CLI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http:// | + | 1LEV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=F6P:'>F6P</scene>, <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=CLI:'>CLI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LEV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Bauer, P | + | [[Category: Bauer, P H.]] |
| - | [[Category: Carlo, A | + | [[Category: Carlo, A A.]] |
| - | [[Category: Danley, D | + | [[Category: Danley, D E.]] |
| - | [[Category: Hageman, D | + | [[Category: Hageman, D L.]] |
| - | [[Category: Karam, G | + | [[Category: Karam, G A.]] |
| - | [[Category: Mansour, M | + | [[Category: Mansour, M N.]] |
| - | [[Category: McClure, L | + | [[Category: McClure, L D.]] |
[[Category: Pandit, J.]] | [[Category: Pandit, J.]] | ||
| - | [[Category: Schulte, G | + | [[Category: Schulte, G K.]] |
| - | [[Category: Treadway, J | + | [[Category: Treadway, J L.]] |
| - | [[Category: Wang, I | + | [[Category: Wang, I K.]] |
| - | [[Category: Wright, S | + | [[Category: Wright, S W.]] |
[[Category: CLI]] | [[Category: CLI]] | ||
[[Category: F6P]] | [[Category: F6P]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:21 2008'' |
Revision as of 11:44, 21 February 2008
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PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR
Overview
3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The compound binds at the AMP regulatory site by X-ray crystallography. This represents a new approach to inhibition of fructose 1,6-bisphosphatase and serves as a lead for further drug design.
About this Structure
1LEV is a Single protein structure of sequence from Sus scrofa with , and as ligands. Active as Fructose-bisphosphatase, with EC number 3.1.3.11 Full crystallographic information is available from OCA.
Reference
3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:12781194
Page seeded by OCA on Thu Feb 21 13:44:21 2008
Categories: Fructose-bisphosphatase | Single protein | Sus scrofa | Bauer, P H. | Carlo, A A. | Danley, D E. | Hageman, D L. | Karam, G A. | Mansour, M N. | McClure, L D. | Pandit, J. | Schulte, G K. | Treadway, J L. | Wang, I K. | Wright, S W. | CLI | F6P | MN | Hydrolase
