1nci
From Proteopedia
(New page: 200px<br /><applet load="1nci" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nci, resolution 2.1Å" /> '''STRUCTURAL BASIS OF C...) |
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| - | [[Image:1nci.gif|left|200px]]<br /><applet load="1nci" size=" | + | [[Image:1nci.gif|left|200px]]<br /><applet load="1nci" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1nci, resolution 2.1Å" /> | caption="1nci, resolution 2.1Å" /> | ||
'''STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS'''<br /> | '''STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Crystal structures of the amino-terminal domain of N-cadherin provide a | + | Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells. |
==About this Structure== | ==About this Structure== | ||
| - | 1NCI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with IUM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1NCI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=IUM:'>IUM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Als-Nielsen, J.]] | [[Category: Als-Nielsen, J.]] | ||
| - | [[Category: Colman, D | + | [[Category: Colman, D R.]] |
| - | [[Category: Fannon, A | + | [[Category: Fannon, A M.]] |
[[Category: Grubel, G.]] | [[Category: Grubel, G.]] | ||
| - | [[Category: Hendrickson, W | + | [[Category: Hendrickson, W A.]] |
| - | [[Category: Kwong, P | + | [[Category: Kwong, P D.]] |
| - | [[Category: Legrand, J | + | [[Category: Legrand, J F.]] |
| - | [[Category: Lehmann, M | + | [[Category: Lehmann, M S.]] |
[[Category: Shapiro, L.]] | [[Category: Shapiro, L.]] | ||
[[Category: Thompson, A.]] | [[Category: Thompson, A.]] | ||
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[[Category: cadherin]] | [[Category: cadherin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:38 2008'' |
Revision as of 12:04, 21 February 2008
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STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
Overview
Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.
About this Structure
1NCI is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis of cell-cell adhesion by cadherins., Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grubel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA, Nature. 1995 Mar 23;374(6520):327-37. PMID:7885471
Page seeded by OCA on Thu Feb 21 14:04:38 2008
