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1npu
From Proteopedia
(New page: 200px<br /><applet load="1npu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1npu, resolution 2.00Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1npu.gif|left|200px]]<br /><applet load="1npu" size=" | + | [[Image:1npu.gif|left|200px]]<br /><applet load="1npu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1npu, resolution 2.00Å" /> | caption="1npu, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''<br /> | '''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell | + | PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family. |
==About this Structure== | ==About this Structure== | ||
| - | 1NPU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1NPU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Almo, S | + | [[Category: Almo, S C.]] |
[[Category: Cao, E.]] | [[Category: Cao, E.]] | ||
[[Category: Chen, L.]] | [[Category: Chen, L.]] | ||
[[Category: Guo, X.]] | [[Category: Guo, X.]] | ||
| - | [[Category: NYSGXRC, New | + | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] |
| - | [[Category: Nathenson, S | + | [[Category: Nathenson, S G.]] |
| - | [[Category: Schwartz, J | + | [[Category: Schwartz, J C.D.]] |
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
| - | [[Category: Zhang, Z | + | [[Category: Zhang, Z Y.]] |
[[Category: ig v-type domain]] | [[Category: ig v-type domain]] | ||
[[Category: new york structural genomix research consortium]] | [[Category: new york structural genomix research consortium]] | ||
| Line 29: | Line 29: | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:08:41 2008'' |
Revision as of 12:08, 21 February 2008
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1
Overview
PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that PD-1 is monomeric both in solution as well as on cell surface, in contrast to CTLA-4 and other family members that are all disulfide-linked homodimers. Furthermore, our structure-based mutagenesis studies identify the ligand binding surface of PD-1, which displays significant differences compared to those present in the other members of the family.
About this Structure
1NPU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural and functional analysis of the costimulatory receptor programmed death-1., Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC, Immunity. 2004 Mar;20(3):337-47. PMID:15030777
Page seeded by OCA on Thu Feb 21 14:08:41 2008
Categories: Mus musculus | Single protein | Almo, S C. | Cao, E. | Chen, L. | Guo, X. | NYSGXRC, New York Structural GenomiX Research Consortium. | Nathenson, S G. | Schwartz, J C.D. | Zhang, X. | Zhang, Z Y. | Ig v-type domain | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Structural genomics
