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1sl3

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==About this Structure==
==About this Structure==
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[[1sl3]] is a 2 chain structure of [[Hirudin]] and [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SL3 OCA].
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[[1sl3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SL3 OCA].
==See Also==
==See Also==

Revision as of 22:25, 20 October 2012

Image:1sl3.png

Template:STRUCTURE 1sl3

Contents

crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor

Template:ABSTRACT PUBMED 15163182

About this Structure

1sl3 is a 2 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Young MB, Barrow JC, Glass KL, Lundell GF, Newton CL, Pellicore JM, Rittle KE, Selnick HG, Stauffer KJ, Vacca JP, Williams PD, Bohn D, Clayton FC, Cook JJ, Krueger JA, Kuo LC, Lewis SD, Lucas BJ, McMasters DR, Miller-Stein C, Pietrak BL, Wallace AA, White RB, Wong B, Yan Y, Nantermet PG. Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors. J Med Chem. 2004 Jun 3;47(12):2995-3008. PMID:15163182 doi:10.1021/jm030303e

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