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1aq1
From Proteopedia
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Revision as of 12:45, 30 October 2007
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE
Overview
Staurosporine exhibits nanomolar IC50 values against a wide range of, protein kinases. The structure of a CDK2 staurosporine complex explains, the tight binding of this inhibitor, and suggests features to be exploited, in the design of specific inhibitors of CDKs.
About this Structure
1AQ1 is a [Single protein] structure of sequence from [Homo sapiens] with STU as [ligand]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: STB. Full crystallographic information is available from [OCA].
Reference
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743
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