1oz3
From Proteopedia
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==Overview== | ==Overview== | ||
| - | We report on the X-ray structure of three 100-amino acid mbt repeats in | + | We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Boccuni, P.]] | [[Category: Boccuni, P.]] | ||
[[Category: MacGrogan, D.]] | [[Category: MacGrogan, D.]] | ||
| - | [[Category: Nimer, S | + | [[Category: Nimer, S D.]] |
| - | [[Category: Patel, D | + | [[Category: Patel, D J.]] |
[[Category: Tereshko, V.]] | [[Category: Tereshko, V.]] | ||
| - | [[Category: Wang, W | + | [[Category: Wang, W K.]] |
[[Category: MES]] | [[Category: MES]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: three malignant brain tumor]] | [[Category: three malignant brain tumor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:23:17 2008'' |
Revision as of 12:23, 21 February 2008
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Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom
Overview
We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.
About this Structure
1OZ3 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets., Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ, Structure. 2003 Jul;11(7):775-89. PMID:12842041
Page seeded by OCA on Thu Feb 21 14:23:17 2008
