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1awy
From Proteopedia
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Revision as of 12:47, 30 October 2007
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NMR STRUCTURE OF CALCIUM BOUND CONFORMER OF CONANTOKIN G, MINIMIZED AVERAGE STRUCTURE
Overview
Conantokin G is a gamma-carboxyglutamic acid- (Gla-) containing conotoxin, isolated from the venom of the marine cone snail Conus geographus. This, 17-residue polypeptide, which contains five gamma-carboxyglutamic acid, residues, is a N-methyl-d-aspartate- (NMDA-) type glutamate receptor, antagonist. To investigate the role of gamma-carboxyglutamic acid in the, calcium-induced structural transition of conantokin G, we determined the, three-dimensional structure of the conantokin G/Ca2+ complex by, two-dimensional 1H NMR spectroscopy and compared it to the high-resolution, structure of conantokin G in the absence of metal ions [Rigby et al., (1997) Biochemistry 36, 6906]. Complete resonance assignments were made by, two dimensional 1H NMR spectroscopy at pH 5.6 in the presence of, ... [(full description)]
About this Structure
1AWY is a [Single protein] structure of sequence from [Conus geographus] with NH2 as [ligand]. Structure known Active Site: CA1. Full crystallographic information is available from [OCA].
Reference
Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus., Rigby AC, Baleja JD, Li L, Pedersen LG, Furie BC, Furie B, Biochemistry. 1997 Dec 16;36(50):15677-84. PMID:9398296
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