4acf

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-	'''Unreleased structure'''	+	[[Image:4acf.jpg|left|200px]]
-	The entry 4acf is ON HOLD until Paper Publication	+	{{STRUCTURE_4acf| PDB=4acf | SCENE= }}
-	Authors: Nilsson, M.T., Mowbray, S.L.	+	===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.===
-	Description: CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.	+	{{ABSTRACT_PUBMED_16027359}}
		+
		+	==About this Structure==
		+	[[4acf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ACF OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:016027359</ref><ref group="xtra">PMID:019695264</ref><references group="xtra"/>
		+	[[Category: Glutamate--ammonia ligase]]
		+	[[Category: Mycobacterium tuberculosis h37rv]]
		+	[[Category: Mowbray, S L.]]
		+	[[Category: Nilsson, M T.]]
		+	[[Category: Glna1]]
		+	[[Category: Ligase]]
		+	[[Category: Mt2278]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Rv2220]]
		+	[[Category: Synthetase]]
		+	[[Category: Taut state]]
		+	[[Category: Tri-substituted imidazole]]

---

Revision as of 07:42, 24 October 2012

Template:STRUCTURE 4acf

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS GLUTAMINE SYNTHETASE IN COMPLEX WITH IMIDAZOPYRIDINE INHIBITOR ((4-(6-BROMO-3-(BUTYLAMINO)IMIDAZO(1,2-A)PYRIDIN-2-YL)PHENOXY) ACETIC ACID) AND L-METHIONINE-S-SULFOXIMINE PHOSPHATE.

Template:ABSTRACT PUBMED 16027359

About this Structure

4acf is a 6 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.

Reference

• Krajewski WW, Jones TA, Mowbray SL. Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10499-504. Epub 2005 Jul 18. PMID:16027359
• Nilsson MT, Krajewski WW, Yellagunda S, Prabhumurthy S, Chamarahally GN, Siddamadappa C, Srinivasa BR, Yahiaoui S, Larhed M, Karlen A, Jones TA, Mowbray SL. Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors. J Mol Biol. 2009 Oct 23;393(2):504-13. Epub 2009 Aug 18. PMID:19695264 doi:10.1016/j.jmb.2009.08.028