This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Beta-lactamase
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:3bm6.png|left|200px|thumb|Crystal Structure of Beta-lactamase, [[3bm6]]]] | [[Image:3bm6.png|left|200px|thumb|Crystal Structure of Beta-lactamase, [[3bm6]]]] | ||
{{STRUCTURE_3bm6| PDB=3bm6 | SIZE=400| SCENE=Beta-lactamase/Beta-lactamase/1|right|CAPTION=Beta-lactamase class D dimer complex with boronic acid derivative, [[3bm6]] }} | {{STRUCTURE_3bm6| PDB=3bm6 | SIZE=400| SCENE=Beta-lactamase/Beta-lactamase/1|right|CAPTION=Beta-lactamase class D dimer complex with boronic acid derivative, [[3bm6]] }} | ||
| + | |||
| + | |||
| + | |||
| + | |||
| + | |||
Revision as of 09:16, 25 October 2012
Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.
3D Structures of Beta-lactamase
Update June 2012
β-lactamase class A
3dtm, 1bza, 1ck3, 1esu, 1jwp, 1lhy, 1li0, 1m40, 1zg6, 2v1z, 2v20, 3cmz, 3jyi - EcBlac A Tem-1 (mutant) - Escherichia coli
1btl, 1iys, 1xpb, 1zg4 - EcBlac A Tem-1
1lhy - EcBlac A Tem-30 (mutant)
1li0 - EcBlac A Tem-32 (mutant)
1li9 - EcBlac A Tem-34 (mutant)
1yt4 - EcBlac A Tem-76 (mutant)
3toi - EcBlac A Tem-116 (mutant)
1we4, 2xr0, 2zq7, 2zq8, 2zq9, 2zqa, 2zqc, 2zqd - EcBlac A Toho-1 (mutant)
2xqz, 2wyx - EcBlac A Toho-1 (mutant) – Neutron
3c5a – EcBlac A Kpc-2
1ylj, 1ylp, 1ylt, 1ylw, 1yly, 1ylz, 1ym1, 1yms, 1ymx, 2p74 – EcBlac A Ctx-M
3hre - EcBlac A Ctx-M (mutant)
1o7e, 1n4o – StmBlac A – Stenotrophonas maltophilia
1htz – KpBlac A Tem-52 – Klebsiella pneumoniae
1shv - KpBlac A Shv-1
1tdl, 2a3u, 3oph, 3opl - KpBlac A Shv-1 (mutant)
1n9b – KpBlac A Shv-2
2qpn – KpBlac A Ges-1
3ni9 - PaBlac A Ges-2
1hzo – Blac A – Proteus vulgaris
1kge, 1kgf, 1kgg, 1ome– SaBlac A (mutant) - Staphylococcus aureus
3blm – SaBlac A
1mbl, 3ly3, 3soi – BlBlac A (mutant) – Bacillus licheniformis
2blm, 3sh7 – BlBlac A
2cc1 – Blac A – Mycobacterium fortuitum
3bfd, 3bfe – CsBlac A Sed-1 (mutant) - Citrobacter sedlakii
β-lactamase class A binary complex
1axb - EcBlac A (mutant) + transition state analog
1tem, 1bt5, 1fqg, 1iyo, 1iyp, 1iyq, 1jvj, 3q07, 3q1f - EcBlac A (mutant) + antibiotic
1nxy, 1ny0, 1nym, 1nyy - EcBlac A (mutant) + boronic acid inhibitor
1pzo, 1pzp - EcBlac A Tem-1 (mutant) + inhibitor
1erm, 1ero, 1erq – EcBlac A Tem-1 + boronic acid inhibitor
3g2y, 3g2z, 3g30, 3g31, 3g32, 3g34, 3g35, 4dds, 4ddy, 4de0, 4de1, 4de2, 4de3 - EcBlac A Ctx-M + inhibitor
3hlw, 3huo, 3hvf - EcBlac A Ctx-M (mutant) + antibiotic
1jwv, 1jwz - EcBlac A Tem-1 (mutant) + boronic acid inhibitor
1ong, 1q2p, 1vm1, 2h5s, 2zd8, 3d4f, 3mke, 3mkf, 3mxr, 3mxs - KpBlac A Shv-1 + inhibitor
1rcj, 1tdg, 2a49, 2h0t, 2h0y, 2h10 - KpBlac A Shv-1 (mutant) + inhibitor
3opp, 3opr- KpBlac A Shv-1 (mutant) + antibiotic
1w7f, 3b3x, 2y91 - BlBlac A + inhibitor
3m2j - BlBlac A (mutant) + inhibitor
2wk0, 2x71– BlBlac A + antibiotic
3ly4, 3m2k, 3sh8, 3sh9 - BlBlac A (mutant) + antibiotic
2q9m, 2q9n - EncBlac A + inhibitor – Enterobacter cloacae
3bfc, 3bff, 3bfg – CsBlac A Sed-1 (mutant) + inhibitor
3nia - PaBlac A Ges-2 + inhibitor
3p98 – Blac Tem-72 + citrate – Morganella morganii
β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
3c7u, 3c7v, 1jtg, 2b5r – EcBlac A (mutant) + Protein Blip
1jtd, 3gmw - EcBlac A + Protein Blip
1s0w, 1xxm - EcBlac A + Protein Blip (mutant)
2g2u - KpBlac A Shv-1 + Protein Blip
2g2w, 3n4i - KpBlac A Shv-1 (mutant) + Protein Blip
3c4o, 3c4p - KpBlac A Shv-1 + Protein Blip (mutant)
3e2k, 3e2l - KpBlac A Kpc-2 (mutant) + Protein Blip
3qhv, 2qhy - Blac A + Protein Blip – Bacillus anthracis
β-lactamase class B (Zn containing)
3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15, 1bc2, 1bvt, 1mqo, 2bc2, 3bc2, 1bmc – BcBlac B - Bacillus cereus
3knr, 3kns, 1dxk, 2bfk, 2bfl, 2bfz, 2bg2, 2bg6, 2bg7, 2bg8, 2bga, 2nxa, 2nyp, 2nze, 2nzf, 2uyx - BcBlac B (mutant)
1a7t, 1znb, 2bmi – BfBlac B – Bacterioides fragilis
2znb - BfBlac B (Cd)
3znb – BfBlac B (Zn, Hg)
4znb - BfBlac B (mutant)
1k07 – FgBlac B]] - Fluoribacter gormanii
1l9y - FgBlac B (mutant)
1ko2, 1ko3 – PaBlac B Vim-2 - Pseudomonas aeruginosa
2whg, 2wrs - PaBlac B Vim-4
2y87, 2y8a, 2y8b - PaBlac B Vim-7
2fhx - PaBlac B Spm-1
2x01 - PaBlac Oxa-10 (mutant)
2x02 - PaBlac Oxa-10
1wuo, 1wup - SmBlac Imp-1 (mutant) – Serratia marcescens
2dkf, 2zo4, 2zwr – TtBlac B – Thermus thermophilus
2zzi – TtBlac B (Fe)
2fm6, 2fu6, 2fu7, 2h6a – StmMlac B
2qin, 2qjs - StmBlac B (mutant)
2gmn, 3lvz – BjBlac B – Bradyrhizobium japonicum
2p4z – Blac B – Thermoanaerobacter tengcongensis
3f9o - AhBlac B – Aeromonas hydrophila
3fai, 1x8h - AhBlac B (mutant)
3l6n – Blac B – Chryseobacter indolegenes
3r2u – SaBlac B
3rkj, 3sbl, 3sfp, 3spu, 3zr9 - KpBlac B Ndm-1
3srx - KpBlac B Ndm-1 (Cd)
3rkk - KpBlac B Ndm-1 (mutant)
3s0z - EcBlac B Ndm-1
2yz3 – Blac Vim-2 – Pseudomonas putida
3sd9 – SfBlac B - Serratia fonticola
β-lactamase class B binary complex
1a8t, 1hlk, 1kr3 - BfBlac B + inhibitor
1jt1 – FgBlac + captopril
1jje, 1jjt, 3lce - PaBlac B + inhibitor
1m2x – Blac B + captopril – Elizabethkingia meningoseptica
1vgn - SmBlac Imp-1+ inhibitor
2doo - SmBlac Imp-1+ fluorescent agent
2aio – StmBlac B + antibiotic
2fu8, 2fu9, 2gfj, 2gfk, 2hb9, 2qdt - StmBlac B + inhibitor
3iof, 1x8i, 3iog– AhBlac B (mutant) + inhibitor
1x8g, 2gkl – AhBlac B + inhibitor
2qds – AhBlac B + captopril
3m8t – BjBlac B + inhibitor
3q6v – SfBlac B + glycerol
3q6x – KpBlac B Ndm-1+ antibiotic
β-lactamase class C
3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)
1zkj – Blac C – Enterobacter aerogenes
2qz6 – Blac C – Pseudomonas fluorescens
β-lactamase class C binary complex
3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid inhibitor
3ixb, 3ixg - EcBlac C (mutant) + boronic acid inhibitor
3ixh - EcBlac C (mutant) + cefotaxime
3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb - EcBlac C + inhibitor
1onh, 1q2q, 1y54 - EncBlac C + inhibitor
1s6r - EncBlac C+ boronic acid inhibitor
1rgz - EncBlac C + antribiotic
1rgy - CfBlac C + antribiotic – Citrobacter freundii
1zc2, 2zc7 – KpBlac C + inhibitor
2wzx, 2wzz – PaBlac C + inhibitor
β-lactamase class D
2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof, 1ddk, 1e3u, 1e4d, 1h8z – PaBlac D
2hp5, 2hp6, 2hp9, 2hpb, 2wgw, 2wki - PaBlac D (mutant)
1k56, 2k02 - PaBlac Pse-2
1g68, 1k4f – PaBlac Pse-4
1g6a – PaBlac Pse-4 (mutant)
1ko2 – PaBlac Vim-2
1k38 – Blac D – Salmonella typhimurium
1m6k – EcBlac D
3hbr – KpBlac D Oxa-48
3if6 - KpBlac D Oxa-46
β-lactamase class D binary complex
1k6r, 1k54 - PaBlac D + antibiotic
2wgi, 2wkh - PaBlac D (mutant) + antibiotic
1k6s - PaBlac D + phenylboronic acid
1dd6, 1h5x, 1h8y, 2wgv - PaBlac D + inhibitor
3isg – EcBlac D + inhibitor
3pae, 3pag - AbBlac D (mutant) + inhibitor
AmpC β-lactamase
1ke4, 2bls, 2zj9, 3bls – EcBlac
1l0d, 1l0e, 1l0f, 1l0g - EcBlac (mutant)
1fcn – EcBlac (mutant) + substrate
1fco, 1i5q, 1kvl - EcBlac (mutant) + antibiotic
1iel, 1fcm, 1iem, 1kvm, 1ll5, 1ll9, 1llb - EcBlac + antibiotic
1fsw, 1fsy, 1kds, 1kdw, 1ke0, 1ke3, 1mxo, 1my8 - EcBlac + boronic acid inhibitor
1pi4, 1pi5, 2ffy - EcBlac (mutant) + boronic acid inhibitor
1l2s, 1xgi, 1xgj, 2hdq, 2hdr, 2hds, 2hdu, 2p9v, 2pu2, 2pu4, 2r9w, 2r9x, 2rcx - EcBlac + inhibitor
1o07 - EcBlac (mutant) + inhibitor
3s1y, 3s22 - PaBlac (mutant) + inhibitor
Non-classified β-lactamase
1bsg – Blac – Streptomyces albus
1alq, 1blp, 1dja, 1djb, 1djc, 1ghi – SaBlac (mutant)
1gce, 1xx2 - EncBlac
1dy6 – SmBlac Sme-1
1fr1, 1fr6 – CfBlac
1i2s – BlBlac
2gdn – MtBlac – Mycobacterium tuberculosis
2jc7, 3g4p – AbBlac – Acinetobacter baumannii
3byd – Blac – Klebsiella oxytoca
3i7j – Blac – Mycobacterium bovis
3lez – Blac – Oceanobacter iheyensis
3p09 – Blac – Francisella tularensis
4blm - BlBlac
Non-classified β-lactamase binary complex
1ghm, 1ghp, 1pio - SaBlac (mutant) + antibiotic
1blc, 1blh– SaBlac + inhibitor
1bls – EncBlac + phosphonate derivative
1bul - EncBlac + penicillin derivative
1ga0 - EncBlac + inhibitor
1i2w – BlBlac + cifoxitin
3cg5 – MtBlac + antibiotic
3n8s, 3ny4, 3n6i, 3n7w, 3n8l, 3n8r, 3nbl, 3nc8, 3nck, 3nde, 3ndg - MtBlac (mutant) + antibiotic
3dwz, 3iqa, 3m6b, 3m6h – MtBlac + inhibitor
3fv7, 3fyz, 3fzc, 3mbz – AbBlac + inhibitor
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
